Omicron infects young children more easily than other variants; loss of smell can be a precursor to memory loss

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Here is a summary of some recent studies on COVID-19[feminine]. They include research that deserves further study to corroborate the findings and that has not yet been certified by peer review.

Children’s noses defend less well against Omicron

The Omicron variant may be more effective at infecting children through the nose than previous versions of the coronavirus, a small study suggests.

Earlier in the pandemic, children’s noses had been less hospitable to the virus that causes COVID-19 than adult noses. Studies of the original SARS-CoV-2 and some of its variants found that the virus encountered stronger immune responses in cells lining young noses than in adult nasal cells, and it was less efficient at reproducing in the children. nose. But recent test-tube experiments mixing the virus with nasal cells from 23 healthy children and 15 healthy adults found that the antiviral defenses in the children’s noses “were markedly less pronounced in the case of Omicron”, researchers reported in PLOS Biology on Monday. They also report that Omicron replicated more efficiently in children’s nasal cells compared to Delta and the original virus.

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“These data are consistent with the increase in the number of pediatric infections observed during the Omicron wave,” the researchers wrote, while calling for additional studies.

Two young children wear face masks as they play in the snow in Bryant Park during the COVID pandemic in the Manhattan borough of New York City, New York, U.S. January 14, 2022.

Two young children wear face masks as they play in the snow in Bryant Park during the COVID pandemic in the Manhattan borough of New York City, New York, U.S. January 14, 2022.
(REUTERS/Carlo Allegri)

Smell problems may predict memory problems after COVID-19

According to an Argentinian study, the severity of smell dysfunction after coronavirus infection may be a better predictor of long-term cognitive impairment than the overall severity of COVID-19.

The researchers studied a random sample of 766 people over the age of 60, around 90% of whom had been infected with the virus. Physical, cognitive and neuropsychiatric tests performed three to six months after infection showed some degree of memory impairment in two-thirds of infected participants. After accounting for individuals’ other risk factors, the severity of the loss of smell, known as anosmia, “but not the clinical condition, significant (predicted) cognitive impairment”, reported the researchers on Sunday at the 2022 Alzheimer’s Association International Conference held online and in San Diego.

“The more ideas we have about the causes or at least about the people who will suffer the significant long-term cognitive impact of COVID-19 infection, the better we can track it and start developing methods to prevent it,” Gabriela Gonzalez-Aleman, head of the study from the Pontificia Universidad Catolica Argentina in Buenos Aires, said in a statement.

Vaccine mandates tied to better nursing home staffing

In U.S. states that have mandated COVID-19 vaccines for nursing home staffthe rules achieved the desired effect and did not lead to mass resignations or staff shortages, a study found.

In states without such mandates, however, nursing homes experienced staffing shortages during the study period, researchers in the JAMA Health Forum reported Friday. Data collected from mid-June to mid-November 2021 from the National Healthcare Safety Network showed that in 12 states with COVID-19 vaccination mandates, staff vaccination coverage rates ranged from 78, 7% to 95.2%. Non-mandated states “consistently had lower staff immunization coverage throughout the study window” and “higher rates of reported staff shortages throughout the study period,” according to the report.

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“The mandates’ association with higher vaccine coverage contrasts with previous efforts to increase uptake of the COVID-19 vaccine among nursing home staff through education, outreach, and incentives,” the officials said. researchers. They added that the data “suggests that fears of massive staffing shortages due to vaccination mandates may be unfounded.”

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